WAC (gene)

WAC
Identifiers
Aliases	WAC, BM-016, PRO1741, Wwp4, DESSH, WW domain containing adaptor with coiled-coil
External IDs	OMIM: 615049; MGI: 2387357; HomoloGene: 41148; GeneCards: WAC; OMA:WAC - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	28,623,112 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	7,929,028 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; secondary oocyte; ; Brodmann area 23; ; germinal epithelium; ; caput epididymis; ; tail of epididymis; ; corpus epididymis; ; parietal pleura; ; superficial temporal artery; ; amniotic fluid;
	Top expressed in
	genital tubercle; ; tail of embryo; ; human fetus; ; lateral septal nucleus; ; ventromedial nucleus; ; neural layer of retina; ; body of femur; ; ciliary body; ; medullary collecting duct; ; mammillary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II complex binding; chromatin binding; protein binding;
Cellular component	nuclear speck; spliceosomal complex; nucleus; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; histone monoubiquitination; positive regulation of macroautophagy; regulation of transcription, DNA-templated; histone H2B conserved C-terminal lysine ubiquitination; transcription, DNA-templated; cellular response to DNA damage stimulus; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	51322
	225131
	ENSG00000095787
	ENSMUSG00000024283
	Q9BTA9
	Q924H7
	NM_016628; NM_100264; NM_100486
	NM_001146298; NM_001282093; NM_153085; NM_001360956
	NP_057712; NP_567822; NP_567823
	NP_001139770; NP_001269022; NP_694725; NP_001347885
	Wikidata
View/Edit Human	View/Edit Mouse

WW domain-containing adapter protein with coiled-coil is a protein that in humans is encoded by the WAC gene.

The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known.