TXN2

TXN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UVZ, 1W4V, 1W89
Identifiers
Aliases	TXN2, MT-TRX, MTRX, TRX2, COXPD29, thioredoxin 2, TXN
External IDs	OMIM: 609063; MGI: 1929468; HomoloGene: 40849; GeneCards: TXN2; OMA:TXN2 - orthologs
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	77,813,206 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left adrenal gland; ; right lobe of liver; ; gastrocnemius muscle; ; body of stomach; ; left ventricle; ; nucleus accumbens; ; Amygdala; ; right lobe of thyroid gland; ; left lobe of thyroid gland;
	Top expressed in
	right kidney; ; muscle of thigh; ; adrenal gland; ; dentate gyrus of hippocampal formation granule cell; ; lip; ; right ventricle; ; brown adipose tissue; ; ventricular zone; ; embryo; ; proximal tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide-methionine (S)-S-oxide reductase activity; peptide-methionine (R)-S-oxide reductase activity; protein binding; protein-disulfide reductase activity; protein-containing complex binding;
Cellular component	nucleolus; mitochondrion; mitochondrial matrix; soma; dendrite;
Biological process	response to hypoxia; response to hormone; cellular response to nutrient levels; response to organic cyclic compound; response to oxidative stress; glycerol ether metabolic process; response to axon injury; response to glucose; cell redox homeostasis; sulfur amino acid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	25828
	56551
	n/a
	ENSMUSG00000005354
	Q99757
	P97493
	NM_012473
	NM_019913
	NP_036605
	NP_064297
	Wikidata
View/Edit Human	View/Edit Mouse

Thioredoxin, mitochondrial also known as thioredoxin-2 is a protein that in humans is encoded by the TXN2 gene on chromosome 22. This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.