TRIMU 5

TRIMU 5
Names
IUPAC name
L-Tyrosyl-N-{[(3-methylbutyl)amino]acetyl}-D-alaninamide
Systematic IUPAC name
(2R)-2-Amino-3-(4-hydroxyphenyl)-N-[(2R)-1-{2-[(3-methylbutyl)amino]acetamido}-1-oxopropan-2-yl]propanamide
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C19H30N4O4/c1-12(2)8-9-21-11-17(25)23-18(26)13(3)22-19(27)16(20)10-14-4-6-15(24)7-5-14/h4-7,12-13,16,21,24H,8-11,20H2,1-3H3,(H,22,27)(H,23,25,26)/t13-,16?/m1/s1 Y
    Key: QOGVSHVPIMZZRN-JBZHPUCOSA-N Y
  • InChI=1/C19H30N4O4/c1-12(2)8-9-21-11-17(25)23-18(26)13(3)22-19(27)16(20)10-14-4-6-15(24)7-5-14/h4-7,12-13,16,21,24H,8-11,20H2,1-3H3,(H,22,27)(H,23,25,26)/t13-,16?/m1/s1
    Key: QOGVSHVPIMZZRN-JBZHPUCOBN
  • Oc1ccc(C[C@@H](N)C(=O)N[C@H](C)C(=O)NC(=O)CNCCC(C)C)cc1
Properties
C19H30N4O4
Molar mass 378.466
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

TRIMU-5 is a selective agonist of the μ2-opioid receptor and antagonist of the μ1-opioid receptor. It produces analgesia in animals that differs from that of conventional μ-opioid receptor agonists but that can still be blocked by μ-opioid receptor antagonists. TRIMU-5 can also block the analgesic effects of μ-opioid receptor agonists like morphine. In addition to analgesia, TRIMU-5 inhibits gastrointestinal transit, a known effect of μ2-opioid receptor activation.

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