Thymine-DNA glycosylase

TDG
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1WYW, 2D07, 2RBA, 3UFJ, 3UO7, 3UOB, 4FNC, 4JGC, 4XEG, 4Z3A, 4Z47, 4Z7B, 4Z7Z, 5CYS
Identifiers
Aliases	TDG, hThymine-DNA glycosylase, thymine DNA glycosylase
External IDs	OMIM: 601423; MGI: 3645587; HomoloGene: 2415; GeneCards: TDG; OMA:TDG - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	103,988,874 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; visceral pleura; ; tibia; ; endothelial cell; ; epithelium of nasopharynx; ; gingival epithelium; ; parietal pleura; ; amniotic fluid; ; germinal epithelium; ; hair follicle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; transcription coregulator activity; damaged DNA binding; protein binding; double-stranded DNA binding; hydrolase activity; protein kinase C binding; transcription factor binding; DNA N-glycosylase activity; mismatched DNA binding; protein domain specific binding; DNA binding; magnesium ion binding; uracil DNA N-glycosylase activity; ATP binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity; sodium ion binding; chloride ion binding; SUMO binding; protein self-association; G/U mismatch-specific uracil-DNA glycosylase activity;
Cellular component	PML body; plasma membrane; nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; embryo development; negative regulation of chromatin binding; oxidative DNA demethylation; negative regulation of transcription by RNA polymerase II; negative regulation of protein binding; transcription, DNA-templated; cellular response to DNA damage stimulus; depyrimidination; DNA demethylation; base-excision repair; DNA repair; DNA mismatch repair; regulation of gene expression, epigenetic; base-excision repair, AP site formation; regulation of DNA N-glycosylase activity; chromatin organization; regulation of embryonic development;
	Sources:Amigo / QuickGO
Orthologs
	6996
	545124
	ENSG00000139372
	n/a
	Q13569
	n/a
	NM_001008411; NM_003211; NM_001363612
	XM_006521630
	NP_003202; NP_001350541
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. Several bacterial proteins have strong sequence homology with this protein.