TARS (gene)

TARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WWT, 4HWT, 4P3N, 4TTV
Identifiers
Aliases	TARS1, ThrRS, threonyl-tRNA synthetase, TARS, threonyl-tRNA synthetase 1, TTD7
External IDs	OMIM: 187790; MGI: 106314; HomoloGene: 11852; GeneCards: TARS1; OMA:TARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	33,468,091 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	11,399,751 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; islet of Langerhans; ; mucosa of transverse colon; ; gums; ; gingival epithelium; ; ventricular zone; ; buccal mucosa cell; ; epithelium of colon; ; oral cavity; ; cartilage tissue;
	Top expressed in
	primitive streak; ; epiblast; ; endothelial cell of lymphatic vessel; ; seminal vesicula; ; calvaria; ; hair follicle; ; left lobe of liver; ; genital tubercle; ; tail of embryo; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; protein binding; ATP binding; protein homodimerization activity; threonine-tRNA ligase activity; tRNA binding; RNA binding;
Cellular component	extracellular exosome; actin cytoskeleton; cytoplasm; cytosol;
Biological process	tRNA aminoacylation; tRNA aminoacylation for protein translation; protein biosynthesis; threonyl-tRNA aminoacylation;
	Sources:Amigo / QuickGO
Orthologs
	6897
	110960
	ENSG00000113407
	ENSMUSG00000022241
	P26639
	Q9D0R2
	NM_001258437; NM_001258438; NM_152295
	NM_033074
	NP_001245366; NP_001245367; NP_689508
	NP_149065
	Wikidata
View/Edit Human	View/Edit Mouse

Threonyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the TARS gene.

Aminoacyl tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family