Stichodactyla toxin
| ShK domain-like | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Rainbow colored cartoon diagram (N-terminus = blue, C-terminus = red) of an NMR solution structure of the ShK toxin. Sidechains of cysteine residues involved in disulfide linkages are displayed as sticks and the sulfur atoms in these links are colored yellow. | |||||||||
| Identifiers | |||||||||
| Symbol | ShK | ||||||||
| Pfam | PF01549 | ||||||||
| InterPro | IPR003582 | ||||||||
| SMART | SM00254 | ||||||||
| SCOP2 | 1roo / SCOPe / SUPFAM | ||||||||
| TCDB | 8.B.14 | ||||||||
| OPM superfamily | 296 | ||||||||
| OPM protein | 2lg4 | ||||||||
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| Kappa-stichotoxin-She3a | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | ? | ||||||
| UniProt | P29187 | ||||||
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Stichodactyla toxin (ShK, ShkT) is a 35-residue basic peptide from the sea anemone Stichodactyla helianthus that blocks a number of potassium channels. Related peptides form a conserved family of protein domains known as the ShkT domain. Another well-studied toxin of the family is BgK from Bunodosoma granulifera.
An analogue of ShK called ShK-186 or Dalazatide is in human trials as a therapeutic for autoimmune diseases.