PP2 (kinase inhibitor)

PP2
Names
	Preferred IUPAC name 1-tert-Butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Identifiers
CAS Number	172889-27-9 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:78331;
ChemSpider	4712 ;
PubChem CID	4878;
UNII	PK8JPC58XB ;
CompTox Dashboard (EPA)	DTXSID60274447 ;
	InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19);
	SMILES Nc2ncnc(c12)n(C(C)(C)C)nc1-c3ccc(Cl)cc3;
Properties
Chemical formula	C15H16ClN5
Molar mass	301.78 g·mol−1
Appearance	White to off-white solid
Solubility in DMSO	25 mg/ml
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC₅₀=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of epidermal growth factor receptor (480 nM) and practically no inhibition of ZAP-70 (100 μM) and JAK2 (50 μM). Despite its extensive use as a Src-selective inhibitor, recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities.

Names

Preferred IUPAC name 1-tert-Butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Identifiers
CAS Number	172889-27-9^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:78331
ChemSpider	4712^N
PubChem CID	4878
UNII	PK8JPC58XB^Y
CompTox Dashboard (EPA)	DTXSID60274447
InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
SMILES Nc2ncnc(c12)n(C(C)(C)C)nc1-c3ccc(Cl)cc3
Properties
Chemical formula	C₁₅H₁₆ClN₅
Molar mass	301.78 g·mol⁻¹
Appearance	White to off-white solid
Solubility in DMSO	25 mg/ml
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references