PKM2

PKM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T5A, 1ZJH, 3BJF, 3BJT, 3G2G, 3GQY, 3GR4, 3H6O, 3ME3, 3SRD, 3SRF, 3SRH, 3U2Z, 4B2D, 4FXF, 4FXJ, 4G1N, 4JPG, 4QG6, 4QG8, 4QG9, 4QGC, 4RPP, 4WJ8, 4YJ5
Identifiers
Aliases	PKM, CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, pyruvate kinase, muscle, pyruvate kinase M1/2, p58
External IDs	OMIM: 179050; MGI: 97591; HomoloGene: 37650; GeneCards: PKM; OMA:PKM - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	72,231,819 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	59,679,375 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; prefrontal cortex; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; islet of Langerhans; ; right adrenal cortex; ; gastrocnemius muscle; ; left adrenal gland; ; stromal cell of endometrium;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; epiblast; ; granulocyte; ; triceps brachii muscle; ; primary visual cortex; ; superior frontal gyrus; ; skeletal muscle tissue; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; potassium ion binding; metal ion binding; kinase activity; catalytic activity; protein binding; MHC class II protein complex binding; ATP binding; magnesium ion binding; pyruvate kinase activity; RNA binding; cadherin binding; identical protein binding; ADP binding; thyroid hormone binding;
Cellular component	cytoplasm; extracellular vesicle; vesicle; extracellular matrix; myelin sheath; cilium; mitochondrion; extracellular exosome; nucleus; extracellular region; cytosol; secretory granule lumen; ficolin-1-rich granule lumen; pyruvate kinase complex; collagen-containing extracellular matrix;
Biological process	glycolytic process; programmed cell death; phosphorylation; canonical glycolysis; metabolism; cellular response to insulin stimulus; neutrophil degranulation; response to hypoxia; liver development; glucose metabolic process; ATP biosynthetic process; response to nutrient; response to gravity; response to organic substance; response to muscle inactivity; animal organ regeneration; response to insulin; pyruvate biosynthetic process; skeletal muscle tissue regeneration; protein homotetramerization; positive regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5315
	18746
	ENSG00000067225
	ENSMUSG00000032294
	P14618
	P52480
NM_001206796; NM_001206797; NM_001206798; NM_001206799; NM_002654;
	NM_182470; NM_182471; NM_001316318
	NM_001253883; NM_011099
NP_001193725; NP_001193726; NP_001193727; NP_001193728; NP_001303247;
	NP_002645; NP_872270; NP_872271
NP_001240812; NP_035229; NP_001365795; NP_001365796; NP_001365797;
	NP_001365798; NP_001365799; NP_001365800; NP_001365801; NP_001392420
	Wikidata
View/Edit Human	View/Edit Mouse

Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.

PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells.