| PGRMC1 |
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| Identifiers |
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| Aliases | PGRMC1, HPR6.6, MPR, progesterone receptor membrane component 1, Dap1, IZA, 25-Dx |
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| External IDs | OMIM: 300435; MGI: 1858305; HomoloGene: 48457; GeneCards: PGRMC1; OMA:PGRMC1 - orthologs |
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| Gene location (Mouse) |
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| | Chr. | X chromosome (mouse) |
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| | Band | X|X A3.3 | Start | 35,861,859 bp |
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| End | 35,869,732 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - seminal vesicula
- caput epididymis
- corpus epididymis
- tail of epididymis
- bronchial epithelial cell
- Pons
- endometrium
- skin of thigh
- middle temporal gyrus
- pars compacta
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| | Top expressed in | - olfactory epithelium
- transitional epithelium of urinary bladder
- paraventricular nucleus of hypothalamus
- arcuate nucleus
- ventromedial nucleus
- suprachiasmatic nucleus
- anterior amygdaloid area
- lateral septal nucleus
- left lobe of liver
- dorsomedial hypothalamic nucleus
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| | More reference expression data |
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| BioGPS | |
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| Wikidata |
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Progesterone receptor membrane component 1 (abbreviated PGRMC1) is a protein which co-purifies with progesterone binding proteins in the liver and ovary. In humans, the PGRMC1 protein is encoded by the PGRMC1 gene.
The sole biochemical function of PGRMC1 is heme-binding. PGRMC1 shares key structural motifs with cytochrome b5. PGRMC1 binds and activates P450 proteins, which are important in drug, hormone and lipid metabolism. PGRMC1 also binds to PAIR-BP1 (plasminogen activator inhibitor RNA-binding protein-1). However, its expression outside of the reproductive tract and in males suggests multiple functions for the protein. These may include binding to Insig (insulin-induced gene), which regulates cholesterol synthesis.
