Olokizumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from rat) |
| Target | IL6 |
| Clinical data | |
| Trade names | Artlegia |
| Routes of administration | Subcutaneous |
| ATC code | |
| Pharmacokinetic data | |
| Elimination half-life | 31 days |
| Identifiers | |
| CAS Number | |
| DrugBank | |
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| UNII | |
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| Chemical and physical data | |
| Molar mass | 146000 Da |
| (what is this?) (verify) | |
Olokizumab (OKZ) sold under the name Artlegia, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis and COVID-19. It is a humanized monoclonal antibody against the interleukin-6 (IL-6). IL-6 is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases. Olokizumab is the first interleukin-6 (IL-6) inhibitor approved for treatment of rheumatoid arthritis which blocks directly cytokine instead of its receptor. Olokizumab specifically binds to IL-6 at Site 3, blocking IL-6 ability to form hexameric complex. Olokizumab was developed by R-Pharm group, and was launched in 2020.