Nedaplatin

Nedaplatin
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	IV
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name Diammine[(hydroxy-κO)acetato(2-)-κO]platinum;
CAS Number	95734-82-0 ;
PubChem CID	9796440;
ChemSpider	7972206;
UNII	8UQ3W6JXAN;
KEGG	D01416 ;
CompTox Dashboard (EPA)	DTXSID8046878 ;
Chemical and physical data
Formula	C2H8N2O3Pt
Molar mass	303.181 g·mol−1
3D model (JSmol)	Interactive image; coordination form: Interactive image;
	SMILES C(C(=O)[O-])[O-].N.N.[Pt+2]; ; coordination form: O=C1O[Pt-2]([NH3+])([NH3+])OC1;
	InChI InChI=1S/C2H3O3.2H3N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H3;/q-1;;;+2/p-1; Key:GYAVMUDJCHAASE-UHFFFAOYSA-M;
	(verify)

Nedaplatin (INN, marketed under the tradename Aqupla) is a platinum-based antineoplastic drug which is used for cancer chemotherapy. The complex consists of two ammine ligands and the dianion derived from glycolic acid.

Platinum-based drugs are widely employed as antineoplastic agents, especially cisplatin and carboplatin. Due to issues of their toxicity and number of cisplatin-resistant cancer cells, other platinum derivatives have been developed. Nedaplatin is one example of such new drugs.

Clinical data


AHFS/Drugs.com	International Drug Names
Routes of administration	IV
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name Diammine[(hydroxy-κO)acetato(2-)-κO]platinum
CAS Number	95734-82-0^Y
PubChem CID	9796440
ChemSpider	7972206
UNII	8UQ3W6JXAN
KEGG	D01416^Y
CompTox Dashboard (EPA)	DTXSID8046878
Chemical and physical data
Formula	C₂H₈N₂O₃Pt
Molar mass	303.181 g·mol⁻¹
3D model (JSmol)	Interactive image coordination form: Interactive image
SMILES C(C(=O)[O-])[O-].N.N.[Pt+2] coordination form: O=C1O[Pt-2]([NH3+])([NH3+])OC1
InChI InChI=1S/C2H3O3.2H3N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H3;/q-1;;;+2/p-1 Key:GYAVMUDJCHAASE-UHFFFAOYSA-M
(verify)