Necitumumab

Necitumumab
	Necitumumab Fab (blue) bound to EGFR (green). PDB: 6B3S
Monoclonal antibody
Type	Whole antibody
Source	Human
Target	EGFR
Clinical data
Trade names	Portrazza
AHFS/Drugs.com	Multum Consumer Information
License data	US DailyMed: Necitumumab;
Routes of; administration	Intravenous infusion
ATC code	L01FE03 (WHO) ;
Legal status
Legal status	CA: ℞-only; US: ℞-only;
Pharmacokinetic data
Elimination half-life	~14 days
Identifiers
CAS Number	906805-06-9 ;
DrugBank	DB09559 ;
ChemSpider	none;
UNII	2BT4C47RUI;
KEGG	D10018 ;
Chemical and physical data
Formula	C6436H9958N1702O2020S42
Molar mass	144844.87 g·mol−1
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Necitumumab (INN) is a recombinant human IgG1 monoclonal antibody used as an antineoplastic, which is manufactured by Eli Lilly. It binds to the epidermal growth factor receptor (EGFR). The US FDA approved necitumumab under the brand name Portrazza for use with gemcitabine and cisplatin in previously untreated metastatic squamous non-small-cell lung carcinoma (NSCLC). It was counterproductive in non-squamous non-small-cell lung carcinoma.