Nalfurafine

Nalfurafine
Clinical data
Other names	TRK-820, AC-820, MT-9938
AHFS/Drugs.com	International Drug Names
Routes of; administration	Intravenous
ATC code	V03AX02 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Elimination half-life	14 hours (acute);; 25–28 hours (chronic)
Identifiers
	IUPAC name (2E)-N-[(5α,6β)-17-(Cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]-3-(3-furyl)-N-methylacrylamide;
CAS Number	152657-84-6 ; HCl: 152658-17-8 ;
PubChem CID	6445230;
IUPHAR/BPS	1651;
ChemSpider	4949003 ;
UNII	XC41AVD567; HCl: 25CC4N0P8J ;
ChEMBL	ChEMBL267495 ;
PDB ligand	IVB (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID70905119 ;
Chemical and physical data
Formula	C28H32N2O5
Molar mass	476.573 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN([C@@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)/C=C/C7=COC=C7;
	InChI InChI=1S/C28H32N2O5/c1-29(23(32)7-4-18-9-13-34-16-18)20-8-10-28(33)22-14-19-5-6-21(31)25-24(19)27(28,26(20)35-25)11-12-30(22)15-17-2-3-17/h4-7,9,13,16-17,20,22,26,31,33H,2-3,8,10-12,14-15H2,1H3/b7-4+/t20-,22-,26+,27+,28-/m1/s1 ; Key:XGZZHZMWIXFATA-UEZBDDGYSA-N ;
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Nalfurafine (INN, USAN) (brand name Remitch; former developmental code names TRK-820, AC-820, MT-9938) is an antipruritic (anti-itch drug) that is marketed in Japan for the treatment of uremic pruritus in individuals with chronic kidney disease undergoing hemodialysis. It activates the κ-opioid receptor (KOR) and is potent, selective, and centrally active. It was the first selective KOR agonist approved for clinical use. It has also been dubiously referred to as the "first non-narcotic opioid drug" in history.