NLRP4

NLRP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4EWI
Identifiers
Aliases	NLRP4, CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2, NLR family, pyrin domain containing 4, NLR family pyrin domain containing 4
External IDs	OMIM: 609645; MGI: 1890518; HomoloGene: 75315; GeneCards: NLRP4; OMA:NLRP4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,881,855 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	6,108,149 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle; ; gonad; ; sperm; ; right testis; ; left testis; ; lymph node; ; appendix; ; tonsil; ; epithelium of nasopharynx;
	Top expressed in
	primary oocyte; ; zygote; ; secondary oocyte; ; blastocyst; ; embryo; ; blastocyst; ; morula; ; spermatid; ; Gonadal ridge; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATP binding;
Cellular component	cytosol;
Biological process	inflammatory response; regulation of type I interferon production;
	Sources:Amigo / QuickGO
Orthologs
	147945
	83564
	ENSG00000160505
	ENSMUSG00000034690
	Q96MN2
	Q3TKR3
	NM_134444
	NM_031389
	NP_604393
	NP_113566
	Wikidata
View/Edit Human	View/Edit Mouse

NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.

The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM]