NLRP2

NLRP2
Identifiers
Aliases	NLRP2, CLR19.9, NALP2, NBS1, PAN1, PYPAF2, NLR family, pyrin domain containing 2, NLR family pyrin domain containing 2
External IDs	OMIM: 609364; MGI: 3041206; HomoloGene: 56789; GeneCards: NLRP2; OMA:NLRP2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,001,142 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	5,354,034 bp
RNA expression pattern
	Top expressed in
	gonad; ; placenta; ; testicle; ; granulocyte; ; left testis; ; right testis; ; ganglionic eminence; ; mucosa of transverse colon; ; lymph node; ; blood;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; morula; ; ovarian follicle; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	Pyrin domain binding; nucleotide binding; protein binding; ATP binding;
Cellular component	cytoplasm; Golgi apparatus; intracellular membrane-bounded organelle; cytosol;
Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; inflammatory response; innate immune response; immune system process; apoptotic process; negative regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	55655
	232827
ENSG00000278789; ENSG00000275796; ENSG00000277060; ENSG00000275843; ENSG00000275399;
	ENSG00000022556; ENSG00000275082; ENSG00000278682; ENSG00000274638; ENSG00000273992
	ENSMUSG00000035177
	Q9NX02
	n/a
	NM_017852; NM_001174081; NM_001174082; NM_001174083; NM_001348003
	NM_177690
	NP_001167552; NP_001167553; NP_001167554; NP_060322; NP_001334932
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

NACHT, LRR and PYD domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene.

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors(see TLR4). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003).[supplied by OMIM]