Mosher's acid

Mosher's acid
Names
IUPAC names
(R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid
(S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid
Other names
Methoxy(trifluoromethyl)phenylacetic acid, MTPA
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.153.604
EC Number
  • (R): 243-829-5
  • (S): 241-292-1
UNII
  • InChI=1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15) N
    Key: JJYKJUXBWFATTE-UHFFFAOYSA-N N
  • InChI=1/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)
    Key: JJYKJUXBWFATTE-UHFFFAOYAJ
  • COC(C(O)=O)(c1ccccc1)C(F)(F)F
Properties
C10H9F3O3
Molar mass 234.17
Appearance solid
Melting point 46 to 49 °C (115 to 120 °F; 319 to 322 K)
Boiling point 105 to 107 °C (221 to 225 °F; 378 to 380 K) at 1 torr
Hazards
GHS labelling:
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Flash point 110 °C (230 °F; 383 K)
Related compounds
Mosher's acid chloride
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Mosher's acid, or α-methoxy-α-trifluoromethylphenylacetic acid (MTPA) is a carboxylic acid which was first used by Harry Stone Mosher as a chiral derivatizing agent. It is a chiral molecule, consisting of R and S enantiomers.