LS-115509

LS-115509
Clinical data
ATC code	none;
Identifiers
	IUPAC name 4-ethoxy-4-(furan-2-yl)-3-methyl-1-(2-phenylethyl)piperidine;
CAS Number	94876-55-8 ;
PubChem CID	3024404;
ChemSpider	2290335;
UNII	XG2JQX2JDJ;
CompTox Dashboard (EPA)	DTXSID50915236;
Chemical and physical data
Formula	C20H27NO2
Molar mass	313.441 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC1(CCN(CC1C)CCC2=CC=CC=C2)C3=CC=CO3;
	InChI InChI=1S/C20H27NO2/c1-3-23-20(19-10-7-15-22-19)12-14-21(16-17(20)2)13-11-18-8-5-4-6-9-18/h4-10,15,17H,3,11-14,16H2,1-2H3; Key:INLMDDDTZIKNNI-UHFFFAOYSA-N;

LS-115509 is an opioid analgesic related to the 4-phenylpiperidine family. It is comparable to drugs such as prodine and pheneridine, but is distinguished by the presence of an ether group and furan ring at the piperidine 4-position, which are not found in other drugs of this class. In animal studies, it has around 2-3x the potency of morphine depending on what assay is used. Like prodine, it has two stereocenters and four possible enantiomers, but the activity of these has not been tested separately.

Clinical data

ATC code	none
Identifiers
IUPAC name 4-ethoxy-4-(furan-2-yl)-3-methyl-1-(2-phenylethyl)piperidine
CAS Number	94876-55-8^Y
PubChem CID	3024404
ChemSpider	2290335
UNII	XG2JQX2JDJ
CompTox Dashboard (EPA)	DTXSID50915236
Chemical and physical data
Formula	C₂₀H₂₇NO₂
Molar mass	313.441 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCOC1(CCN(CC1C)CCC2=CC=CC=C2)C3=CC=CO3
InChI InChI=1S/C20H27NO2/c1-3-23-20(19-10-7-15-22-19)12-14-21(16-17(20)2)13-11-18-8-5-4-6-9-18/h4-10,15,17H,3,11-14,16H2,1-2H3 Key:INLMDDDTZIKNNI-UHFFFAOYSA-N