LDB3

LDB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YDP
Identifiers
Aliases	LDB3, CMD1C, CMPD3, CYPHER, LDB3Z1, LDB3Z4, LVNC3, MFM4, ORACLE, PDLIM6, ZASP, CMH24, LIM domain binding 3
External IDs	OMIM: 605906; MGI: 1344412; HomoloGene: 134626; GeneCards: LDB3; OMA:LDB3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	86,736,072 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	34,310,639 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; apex of heart; ; body of tongue; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; left ventricle; ; vena cava; ; myocardium of left ventricle; ; atrium;
	Top expressed in
	triceps brachii muscle; ; muscle of thigh; ; medial head of gastrocnemius muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; ankle; ; quadriceps femoris muscle; ; tibialis anterior muscle; ; digastric muscle; ; vastus lateralis muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytoskeletal protein binding; protein binding; metal ion binding; muscle alpha-actinin binding; protein kinase C binding; actin binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; cell projection; pseudopodium; Z discdkac; cytoskeleton; stress fiber; filamentous actin;
Biological process	sarcomere organization; heart development; actin cytoskeleton organization; muscle structure development;
	Sources:Amigo / QuickGO
Orthologs
	11155
	24131
	ENSG00000122367
	ENSMUSG00000021798
	O75112
	Q9JKS4
NM_001080114; NM_001080115; NM_001080116; NM_001171610; NM_001171611;
	NM_007078; NM_001368063; NM_001368064; NM_001368065; NM_001368066; NM_001368067; NM_001368068
NM_001039071; NM_001039072; NM_001039073; NM_001039074; NM_001039075;
	NM_001039076; NM_011918
NP_001073583; NP_001073584; NP_001073585; NP_001165081; NP_001165082;
	NP_009009; NP_001354992; NP_001354993; NP_001354994; NP_001354995; NP_001354996; NP_001354997
NP_001034160; NP_001034161; NP_001034162; NP_001034163; NP_001034164;
	NP_001034165; NP_036048
	Wikidata
View/Edit Human	View/Edit Mouse

LIM domain binding 3 (LDB3), also known as Z-band alternatively spliced PDZ-motif (ZASP), is a protein which in humans is encoded by the LDB3 gene. ZASP belongs to the Enigma subfamily of proteins and stabilizes the sarcomere (the basic units of muscles) during contraction, through interactions with actin in cardiac and skeletal muscles. Mutations in the ZASP gene has been associated with several muscular diseases.