KIAA1279

KIFBP
Identifiers
Aliases	KIFBP, KBP, KIAA1279, TTC20, KIF1 binding protein, kinesin family binding protein, KIF1BP
External IDs	OMIM: 609367; MGI: 1919570; HomoloGene: 9223; GeneCards: KIFBP; OMA:KIFBP - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	69,043,544 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,414,236 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; ventricular zone; ; secondary oocyte; ; paraflocculus of cerebellum; ; right ventricle; ; middle frontal gyrus; ; prefrontal cortex; ; gonad; ; ganglionic eminence; ; Brodmann area 9;
	Top expressed in
	temporal lobe; ; Amygdala; ; olfactory epithelium; ; Region I of hippocampus proper; ; prefrontal cortex; ; anterior horn of spinal cord; ; hippocampus proper; ; facial motor nucleus; ; nucleus accumbens; ; Epithelium of choroid plexus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; kinesin binding;
Cellular component	cytoplasm; cytoskeleton; mitochondrion;
Biological process	multicellular organism development; cell differentiation; mitochondrial transport; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	26128
	72320
	ENSG00000198954
	ENSMUSG00000036955
	Q96EK5
	Q6ZPU9
	NM_015634
	NM_028197
	NP_056449
	NP_082473
	Wikidata
View/Edit Human	View/Edit Mouse

KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene. The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator. Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis, and hence it can be therapeutically used to control Kif15 upregulated cancer cells.