KDM5A

KDM5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JXJ, 2KGG, 2KGI, 3GL6, 5C11, 5E6H, 5IWF, 5IVV, 5ISL, 5CEH, 5IVB
Identifiers
Aliases	KDM5A, RBBP-2, RBBP2, RBP2, JARID1A, lysine demethylase 5A
External IDs	OMIM: 180202; MGI: 2136980; HomoloGene: 3419; GeneCards: KDM5A; OMA:KDM5A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	389,320 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	120,421,535 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; caput epididymis; ; optic nerve; ; nipple; ; tail of epididymis; ; corpus epididymis; ; saphenous vein; ; trabecular bone; ; pericardium; ; testicle;
	Top expressed in
	Rostral migratory stream; ; genital tubercle; ; Gonadal ridge; ; medullary collecting duct; ; pineal gland; ; tail of embryo; ; left lung lobe; ; lobe of cerebellum; ; internal carotid artery; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; chromatin binding; dioxygenase activity; metal ion binding; protein binding; oxidoreductase activity; chromatin DNA binding; histone demethylase activity; core promoter sequence-specific DNA binding; DNA-binding transcription factor activity; histone H3-methyl-lysine-9 demethylase activity; histone H3-tri/di/monomethyl-lysine-4 demethylase activity; zinc ion binding; methylated histone binding; histone binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	cyclin-dependent protein kinase activating kinase holoenzyme complex; nucleoplasm; protein-DNA complex; nucleolus; nucleus; histone methyltransferase complex;
Biological process	male gonad development; regulation of transcription, DNA-templated; rhythmic process; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; circadian regulation of gene expression; transcription, DNA-templated; positive regulation of transcription, DNA-templated; multicellular organism development; spermatogenesis; negative regulation of histone deacetylase activity; histone H3-K9 demethylation; histone H3-K4 demethylation; histone H3-K4 demethylation, trimethyl-H3-K4-specific; regulation of DNA-binding transcription factor activity; chromatin organization; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	5927
	214899
	ENSG00000073614
	ENSMUSG00000030180
	P29375
	Q3UXZ9
	NM_005056; NM_001042603
	NM_145997
	NP_001036068
	NP_666109
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 5A is an enzyme that in humans is encoded by the KDM5A gene.