The following buildings were added to the National Register of Historic Places as part of the John F. Kennedy Space Center MPS Multiple Property Submission (or MPS). This is a partial list of historic places at KSC; full list available via KSC's Environmental Planning - Cultural Resources.
| Resource Name | Also known as | Address | City | County | Added |
| Central Instrumentation Facility | | John F. Kennedy Space Center | Titusville | Brevard County | January 21, 2000 |
| Crawlerway | | John F. Kennedy Space Center | Titusville | Brevard County | January 21, 2000 |
| Headquarters Building | | John F. Kennedy Space Center | Titusville | Brevard County | December 1, 2000 |
| Launch Complex 39 | | John F. Kennedy Space Center | Titusville | Brevard County | May 24, 1973 |
| Launch Complex 39-Pad A | | John F. Kennedy Space Center | Titusville | Brevard County | January 21, 2000 |
| Launch Complex 39-Pad B | | John F. Kennedy Space Center | Titusville | Brevard County | January 21, 2000 |
| Launch Control Center | | John F. Kennedy Space Center | Titusville | Brevard County | January 21, 2000 |
| Missile Crawler Transporter Facilities | | John F. Kennedy Space Center | Titusville | Brevard County | January 21, 2000 |
| Operations and Checkout Building | | John F. Kennedy Space Center | Titusville | Brevard County | January 21, 2000 |
| Press Site-Clock and Flag Pole | | John F. Kennedy Space Center | Titusville | Brevard County | January 21, 2000 |
| Vehicle Assembly Building-High Bay and Low Bay | | John F. Kennedy Space Center | Titusville | Brevard County | January 21, 2000 |