Indium (111In) capromab pendetide

Indium (¹¹¹In) capromab pendetide
Monoclonal antibody
Type	Whole antibody
Source	Mouse
Target	Glutamate carboxypeptidase II
Clinical data
Trade names	Prostascint
ATC code	V09IB04 (WHO) ;
Identifiers
CAS Number	151763-64-3 (capromab); 148805-91-8 (pendetide);
ChemSpider	none;
UNII	03MZ53X1YS;
ChEMBL	ChEMBL1201579 ;
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Indium (¹¹¹In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer. Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single-photon emission computed tomography (SPECT).

Early trials with yttrium (⁹⁰Y) capromab pendetide were also conducted.