Idazoxan

Idazoxan
Clinical data
Routes of; administration	By mouth
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name (±)-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole;
CAS Number	79944-58-4 ;
PubChem CID	54459;
ChemSpider	49184 ;
UNII	Y310PA316B;
ChEMBL	ChEMBL10316 ;
CompTox Dashboard (EPA)	DTXSID6045161 ;
Chemical and physical data
Formula	C11H12N2O2
Molar mass	204.229 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES C1CN=C(N1)C2COC3=CC=CC=C3O2;
	InChI InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13) ; Key:HPMRFMKYPGXPEP-UHFFFAOYSA-N ;
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Idazoxan (INN) is a drug which is used in scientific research. It acts as both a selective α₂-adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. Idazoxan has been under investigation as an antidepressant, but it did not reach the market as such. More recently, it is under investigation as an adjunctive treatment in schizophrenia. Due to its α₂ receptor antagonism, it is capable of enhancing therapeutic effects of antipsychotics, possibly by enhancing dopamine neurotransmission in the prefrontal cortex of the brain, a brain area thought to be involved in the pathogenesis of schizophrenia.

Clinical data

Routes of administration	By mouth
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name (±)-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole
CAS Number	79944-58-4^Y
PubChem CID	54459
ChemSpider	49184^N
UNII	Y310PA316B
ChEMBL	ChEMBL10316^N
CompTox Dashboard (EPA)	DTXSID6045161
Chemical and physical data
Formula	C₁₁H₁₂N₂O₂
Molar mass	204.229 g·mol⁻¹
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES C1CN=C(N1)C2COC3=CC=CC=C3O2
InChI InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)^N Key:HPMRFMKYPGXPEP-UHFFFAOYSA-N^N
^NY (what is this?) (verify)