Interleukin 32

IL32
Identifiers
Aliases	IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, Interleukin 32, IL-32
External IDs	OMIM: 606001; HomoloGene: 128400; GeneCards: IL32; OMA:IL32 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	3,082,192 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; mucosa of transverse colon; ; body of pancreas; ; spleen; ; apex of heart; ; duodenum; ; jejunal mucosa; ; islet of Langerhans; ; muscle of thigh; ; mucosa of ileum;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding;
Cellular component	extracellular region; membrane; cytosol; extracellular space;
Biological process	defense response; cell adhesion; immune response; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9235
	n/a
	ENSG00000008517
	n/a
	P24001
	n/a
NM_001012631; NM_001012632; NM_001012633; NM_001012634; NM_001012635;
	NM_001012636; NM_001012718; NM_001308078; NM_004221
	n/a
NP_001012649; NP_001012650; NP_001012651; NP_001012652; NP_001012653;
	NP_001012654; NP_001012736; NP_001295007; NP_004212; NP_001356516; NP_001356517; NP_001356518; NP_001356519; NP_001356520; NP_001356521; NP_001356522; NP_001356524; NP_001356525; NP_001363852
	n/a
	Wikidata
View/Edit Human

Interleukin 32 (IL32) is proinflammatory cytokine that in humans is encoded by the IL32 gene. Interleukin 32 can be found in higher mammals but not in rodents. It is mainly expressed intracellularly and the protein has nine different isoforms, because the pre-mRNA can be alternatively spliced. The most active and studied isoform is IL-32γ. It was first reported in 2005, although the IL-32 gene was first described in 1992. It does not belong to any cytokine family because there is almost no homology with other cytokines.

mRNA of IL-32 is mostly expressed in immune cells but also can be expressed in other tissues such as spleen, thymus, lung, small intestine, colon, prostate, heart, placenta, liver, muscle, kidney, pancreas and brain.

Interleukin 32 is connected with several diseases, including cancer.