Interleukin 16

IL16
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I16, 1X6D, 5FB8
Identifiers
Aliases	IL16, LCF, NPRprIL-16, IL-16, interleukin 16
External IDs	OMIM: 603035; MGI: 1270855; HomoloGene: 18157; GeneCards: IL16; OMA:IL16 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	81,314,058 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	83,394,934 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; bone marrow cells; ; appendix; ; spleen; ; monocyte; ; lymph node; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; tendon of biceps brachii;
	Top expressed in
	pharynx; ; granulocyte; ; thymus; ; spleen; ; blood; ; tibiofemoral joint; ; mesenteric lymph nodes; ; sciatic nerve; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; CD4 receptor binding;
Cellular component	plasma membrane; intracellular anatomical structure; extracellular region; extracellular space; nucleus; cytoplasm; cytosol; nuclear speck;
Biological process	induction of positive chemotaxis; chemotaxis; viral process; regulation of transcription, DNA-templated; leukocyte chemotaxis; immune response; transcription, DNA-templated; regulation of calcium ion transport; regulation of signaling receptor activity; cytokine-mediated signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	3603
	16170
	ENSG00000172349
	ENSMUSG00000001741
	Q14005
	O54824
NM_001172128; NM_004513; NM_172217; NM_001352684; NM_001352685;
	NM_001352686
	NM_010551; NM_001360087; NM_001360088; NM_001360089
NP_001165599; NP_004504; NP_757366; NP_001339613; NP_001339614;
	NP_001339615
	NP_034681; NP_001347016; NP_001347017; NP_001347018
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 16 is a pro-inflammatory pleiotropic cytokine. Its precursor, pro-interleukin-16 is a protein that in humans is encoded by the IL16 gene. This gene was discovered in 1982 at Boston University by Dr. David Center and Dr. William Cruikshank.