HS665

HS665
Identifiers
	IUPAC name 3-[2-[cyclobutylmethyl(2-phenylethyl)amino]ethyl]phenol;
CAS Number	1409931-92-5;
PubChem CID	71452041;
ChemSpider	28666556;
ChEMBL	ChEMBL2180639;
CompTox Dashboard (EPA)	DTXSID401336626 ;
Chemical and physical data
Formula	C21H27NO
Molar mass	309.453 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC(C1)CN(CCC2=CC=CC=C2)CCC3=CC(=CC=C3)O;
	InChI InChI=1S/C21H27NO/c23-21-11-5-8-19(16-21)13-15-22(17-20-9-4-10-20)14-12-18-6-2-1-3-7-18/h1-3,5-8,11,16,20,23H,4,9-10,12-15,17H2; Key:YNVKFHIWFDRVNY-UHFFFAOYSA-N;

HS665 is a drug which acts as a potent and selective κ-opioid receptor agonist, and has analgesic effects in animal studies. HS665 is not an agonist for the mu receptor, leading to less potential for abuse.

The structure of HS665 is a close analog of an existing compound called RU-24213. RU-24213 has D2-agonist and KOR antagonist pharmacology.

Identifiers

IUPAC name 3-[2-[cyclobutylmethyl(2-phenylethyl)amino]ethyl]phenol
CAS Number	1409931-92-5
PubChem CID	71452041
ChemSpider	28666556
ChEMBL	ChEMBL2180639
CompTox Dashboard (EPA)	DTXSID401336626
Chemical and physical data
Formula	C₂₁H₂₇NO
Molar mass	309.453 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CC(C1)CN(CCC2=CC=CC=C2)CCC3=CC(=CC=C3)O
InChI InChI=1S/C21H27NO/c23-21-11-5-8-19(16-21)13-15-22(17-20-9-4-10-20)14-12-18-6-2-1-3-7-18/h1-3,5-8,11,16,20,23H,4,9-10,12-15,17H2 Key:YNVKFHIWFDRVNY-UHFFFAOYSA-N