Great Fish River Mouth Wetland Nature Reserve
| Great Fish River Mouth Wetland Nature Reserve | |
|---|---|
| Location | Eastern Cape, South Africa |
| Nearest city | Port Alfred |
| Coordinates | 33°28′05″S 27°03′50″E / 33.4680441°S 27.0638993°E |
| Area | 210.85 ha (521.0 acres) |
| Established | 19 February 1988 |
Great Fish River Mouth Wetland Nature Reserve is a wetland nature reserve that lies at the confluence of the Kap River, on the southern bank of the Great Fish River near Port Alfred. Neighbouring it is the Kap River Nature Reserve.