EHMT2

EHMT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2O8J, 3DM1, 3K5K, 3RJW, 4NVQ, 5JJ0, 5JHN, 5JIN
Identifiers
Aliases	EHMT2, BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, euchromatic histone lysine methyltransferase 2
External IDs	OMIM: 604599; MGI: 2148922; HomoloGene: 48460; GeneCards: EHMT2; OMA:EHMT2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,897,687 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,133,028 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; ganglionic eminence; ; putamen; ; ventricular zone; ; right frontal lobe; ; right hemisphere of cerebellum; ; caudate nucleus; ; temporal lobe; ; Amygdala; ; anterior cingulate cortex;
	Top expressed in
	Gonadal ridge; ; spermatid; ; entorhinal cortex; ; ventricular zone; ; seminiferous tubule; ; perirhinal cortex; ; spermatocyte; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; histone methyltransferase activity (H3-K9 specific); promoter-specific chromatin binding; zinc ion binding; C2H2 zinc finger domain binding; histone-lysine N-methyltransferase activity; metal ion binding; histone methyltransferase activity (H3-K27 specific); protein-lysine N-methyltransferase activity; protein binding; p53 binding;
Cellular component	nucleoplasm; chromosome; nucleus; nuclear speck;
Biological process	regulation of DNA replication; cellular response to starvation; negative regulation of transcription by RNA polymerase II; DNA methylation; methylation; peptidyl-lysine dimethylation; histone lysine methylation; histone methylation; histone H3-K27 methylation; histone H3-K9 methylation; negative regulation of G0 to G1 transition; chromatin organization; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	10919
	110147
ENSG00000238134; ENSG00000224143; ENSG00000206376; ENSG00000204371; ENSG00000227333;
	ENSG00000232045; ENSG00000236759
	ENSMUSG00000013787
	Q96KQ7
	Q9Z148
NM_001289413; NM_006709; NM_025256; NM_001318833; NM_001363689;
	NM_001395160; NM_001395161; NM_001395162; NM_001395163; NM_001395164; NM_001395165
	NM_001286573; NM_001286575; NM_145830; NM_147151
	NP_001276342; NP_001305762; NP_006700; NP_079532; NP_001350618
NP_001273502; NP_001273504; NP_665829; NP_671493; NP_001390796;
	NP_001390798; NP_001390799
	Wikidata
View/Edit Human	View/Edit Mouse

Euchromatic histone-lysine N-methyltransferase 2 (EHMT2), also known as G9a, is a histone methyltransferase enzyme that in humans is encoded by the EHMT2 gene. G9a deposits the mono- and di-methylated states of histone H3 at lysine residue 9 (i.e., H3K9me1 and H3K9me2) and lysine residue 27 (H3K27me1 and H3K27me2). The presence of H3K9me1/2 is usually associated with gene silencing.