Fedotozine

Fedotozine
Clinical data
Routes of; administration	Oral
ATC code	None;
Legal status
Legal status	In general: non-regulated;
Identifiers
	IUPAC name (2R)-N,N-dimethyl-2-phenyl-1-[(3,4,5-trimethoxybenzyl)oxy]-2-butanamine;
CAS Number	123618-00-8 ; 133267-27-3 (tartrate);
PubChem CID	6918160;
ChemSpider	5293373;
UNII	F45VW2087W;
ChEMBL	ChEMBL2106275;
CompTox Dashboard (EPA)	DTXSID901318556 ;
Chemical and physical data
Formula	C22H31NO4
Molar mass	373.493 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O(c1cc(cc(OC)c1OC)COC[C@@](c2ccccc2)(N(C)C)CC)C;
	InChI InChI=1S/C22H31NO4/c1-7-22(23(2)3,18-11-9-8-10-12-18)16-27-15-17-13-19(24-4)21(26-6)20(14-17)25-5/h8-14H,7,15-16H2,1-6H3/t22-/m0/s1; Key:MVKIWCDXKCUDEH-QFIPXVFZSA-N;

Fedotozine (INN; JO 1196 for the (-) tartrate salt) is an opioid drug which acts as a peripherally specific selective κ₁-opioid receptor agonist with preference for the κ_1A subtype. It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials, but ultimately development was discontinued and it was never marketed.

Clinical data

Routes of administration	Oral
ATC code	None
Legal status
Legal status	In general: non-regulated
Identifiers
IUPAC name (2R)-N,N-dimethyl-2-phenyl-1-[(3,4,5-trimethoxybenzyl)oxy]-2-butanamine
CAS Number	123618-00-8 133267-27-3 (tartrate)
PubChem CID	6918160
ChemSpider	5293373
UNII	F45VW2087W
ChEMBL	ChEMBL2106275
CompTox Dashboard (EPA)	DTXSID901318556
Chemical and physical data
Formula	C₂₂H₃₁NO₄
Molar mass	373.493 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O(c1cc(cc(OC)c1OC)COC[C@@](c2ccccc2)(N(C)C)CC)C
InChI InChI=1S/C22H31NO4/c1-7-22(23(2)3,18-11-9-8-10-12-18)16-27-15-17-13-19(24-4)21(26-6)20(14-17)25-5/h8-14H,7,15-16H2,1-6H3/t22-/m0/s1 Key:MVKIWCDXKCUDEH-QFIPXVFZSA-N