Type VIII secretion system

A Type VIII secretion system is a type of secretion system found within the inner and outer membranes of gram-negative bacteria. This system is also referred to as the curli biogenesis pathway or the extracellular nucleation-precipitation pathway. It is associated with the formation of biofilms and infecting hosts. Curli formation is especially efficient at evading the host's immune system due to the subunits being able to quickly assemble in a single process and not having intermediates. This system is associated with curli-specific genes and utilizes multiple proteins in its process to form curli fibers. These proteins include CsgA CsgB, CsgC, CsgD, CsgE, CsgF, and CsgG. Type VIII secretion system facilitates the assembly and translocation of curli fibers.

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