Emactuzumab
Emactuzumab light (purple) and heavy (orange) chains complexed with CSF-1R (green) | |
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | CSF1R |
| Clinical data | |
| Other names | RG7155, RO5509554 |
| Routes of administration | intravenous infusion |
| ATC code |
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| Pharmacokinetic data | |
| Elimination half-life | 1.5 - 9 days |
| Identifiers | |
| CAS Number | |
| DrugBank | |
| UNII | |
| KEGG | |
| Chemical and physical data | |
| Formula | C6398H9908N1704O2020S44 |
| Molar mass | 144430.19 g·mol−1 |
Emactuzumab (RG-7155) is a humanized monoclonal antibody directed against colony stimulating factor 1 receptor (CSF-1R) expressed on macrophages and has demonstrated a profound antitumor effect through interference with the CSF-1/CSF-1R axis, along with a manageable safety profile in patients with diffuse-type tenosynovial giant cell tumors (d-TGCT).