Dihydroartemisinin

Dihydroartemisinin
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth
ATC code	P01BE05 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	12%
Metabolism	Liver
Elimination half-life	About 4–11 hours
Excretion	Mainly bile
Identifiers
	IUPAC name (3R,5aS,6R,8aS,9R,12S,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;
CAS Number	71939-50-9 ;
PubChem CID	107770;
ChemSpider	2272104 ;
UNII	6A9O50735X;
ChEMBL	ChEMBL25164 ;
ECHA InfoCard	100.128.242
Chemical and physical data
Formula	C15H24O5
Molar mass	284.352 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O1[C@H](O)[C@@H](C4CC[C@@H](C)[C@H]3[C@@]42OOC(O[C@@H]12)(C)CC3)C;
	InChI InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11?,12+,13-,14?,15-/m1/s1 ; Key:BJDCWCLMFKKGEE-KWWHLYHASA-N ;
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Dihydroartemisinin (also known as dihydroqinghaosu, artenimol or DHA) is a drug used to treat malaria. Dihydroartemisinin is the active metabolite of all artemisinin compounds (artemisinin, artesunate, artemether, etc.) and is also available as a drug in itself. It is a semi-synthetic derivative of artemisinin and is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs. It is sold commercially in combination with piperaquine and has been shown to be equivalent to artemether/lumefantrine.

Clinical data


AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth
ATC code	P01BE05 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	12%
Metabolism	Liver
Elimination half-life	About 4–11 hours
Excretion	Mainly bile
Identifiers
IUPAC name (3R,5aS,6R,8aS,9R,12S,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol
CAS Number	71939-50-9^Y
PubChem CID	107770
ChemSpider	2272104^Y
UNII	6A9O50735X
ChEMBL	ChEMBL25164^N
ECHA InfoCard	100.128.242
Chemical and physical data
Formula	C₁₅H₂₄O₅
Molar mass	284.352 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O1[C@H](O)[C@@H](C4CC[C@@H](C)[C@H]3[C@@]42OOC(O[C@@H]12)(C)CC3)C
InChI InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11?,12+,13-,14?,15-/m1/s1^Y Key:BJDCWCLMFKKGEE-KWWHLYHASA-N^Y
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