CTGF

CCN2
Identifiers
Aliases	CCN2, HCS24, IGFBP8, NOV2, connective tissue growth factor, cellular communication network factor 2, CTGF
External IDs	OMIM: 121009; MGI: 95537; HomoloGene: 1431; GeneCards: CCN2; OMA:CCN2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	131,951,372 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	24,474,581 bp
RNA expression pattern
	Top expressed in
	tibia; ; thoracic aorta; ; ascending aorta; ; smooth muscle tissue; ; gastric mucosa; ; right coronary artery; ; gallbladder; ; Descending thoracic aorta; ; left coronary artery; ; tendon of biceps brachii;
	Top expressed in
	tunica media of zone of aorta; ; stroma of bone marrow; ; ascending aorta; ; semi-lunar valve; ; ankle joint; ; aortic valve; ; skin of external ear; ; ankle; ; ciliary body; ; epithelium of lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibronectin binding; insulin-like growth factor binding; protein C-terminus binding; protein binding; growth factor activity; integrin binding; heparin binding;
Cellular component	cytosol; cis-Golgi network; plasma membrane; extracellular region; cell cortex; perinuclear region of cytoplasm; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	positive regulation of collagen biosynthetic process; positive regulation of cell activation; cell differentiation; regulation of chondrocyte differentiation; response to amino acid; response to estradiol; response to anoxia; intracellular signal transduction; response to mineralocorticoid; response to fatty acid; DNA biosynthetic process; positive regulation of cell death; ossification; response to organic cyclic compound; extracellular matrix constituent secretion; lung development; response to peptide hormone; positive regulation of G0 to G1 transition; positive regulation of JNK cascade; response to glucose; negative regulation of gene expression; reactive oxygen species metabolic process; fibroblast growth factor receptor signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of gene expression; connective tissue development; response to wounding; regulation of cell growth; angiogenesis; tissue homeostasis; positive regulation of cell population proliferation; chondrocyte proliferation; positive regulation of cell differentiation; epidermis development; positive regulation of cardiac muscle contraction; positive regulation of ERK1 and ERK2 cascade; positive regulation of protein phosphorylation; integrin-mediated signaling pathway; transcription initiation from RNA polymerase II promoter; cell-matrix adhesion; cell migration; cartilage condensation; positive regulation of stress fiber assembly; ageing; cell adhesion; cell-cell signaling; negative regulation of cell death; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	1490
	14219
	ENSG00000118523
	ENSMUSG00000019997
	P29279
	P29268
	NM_001901
	NM_010217
	NP_001892
	NP_034347
	Wikidata
View/Edit Human	View/Edit Mouse

CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of cancers.