Blaise reaction
| Blaise reaction | |
|---|---|
| Named after | Edmond E. Blaise |
| Reaction type | Coupling reaction |
| Identifiers | |
| Organic Chemistry Portal | blaise-reaction |
| RSC ontology ID | RXNO:0000237 |
The Blaise reaction is an organic reaction that forms a β-ketoester from the reaction of zinc metal with an α-bromoester and a nitrile. The reaction was first reported by Edmond Blaise (1872–1939) in 1901. The final intermediate is a metaloimine, which is then hydrolyzed to give the desired β-ketoester.
Bulky aliphatic esters tend to give higher yields. Steven Hannick and Yoshito Kishi have developed an improved procedure.
It has been noted that free hydroxyl groups can be tolerated in the course of this reaction, which is surprising for reactions of organometallic halides.