Betacellulin

BTC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IOX, 1IP0
Identifiers
Aliases	BTC, entrez:685, betacellulin
External IDs	OMIM: 600345; MGI: 99439; HomoloGene: 1309; GeneCards: BTC; OMA:BTC - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	74,794,523 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	91,550,853 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; skin of thigh; ; skin of hip; ; gastric mucosa; ; Descending thoracic aorta; ; olfactory zone of nasal mucosa; ; bronchial epithelial cell; ; mucosa of paranasal sinus; ; ascending aorta; ; retinal pigment epithelium;
	Top expressed in
	female external genitalia; ; mucous cell of stomach; ; glans of clitoris; ; pyloric antrum; ; epithelium of stomach; ; tunica media of zone of aorta; ; medullary collecting duct; ; skin of back; ; retinal pigment epithelium; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein tyrosine kinase activity; epidermal growth factor receptor binding; growth factor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular region; intracellular anatomical structure; extracellular space; clathrin-coated vesicle membrane;
Biological process	positive regulation of urine volume; positive regulation of fibroblast proliferation; negative regulation of apoptotic process; MAPK cascade; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of mitotic nuclear division; positive regulation of cell division; regulation of cell motility; phosphatidylinositol phosphate biosynthetic process; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; peptidyl-tyrosine phosphorylation; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; signal transduction; negative regulation of epidermal growth factor receptor signaling pathway; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	685
	12223
	ENSG00000174808
	ENSMUSG00000082361
	P35070
	Q05928
	NM_001729; NM_001316963
	NM_007568
	NP_001303892; NP_001720
	NP_031594
	Wikidata
View/Edit Human	View/Edit Mouse

Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. Betacellulin was initially identified as a mitogen. Betacellulin, is a part of an Epidermal Growth Factor (EGF) family and functions as a ligand for the epidermal growth factor receptor (EGFR). The role of betacellulin as an EGF is manifested differently in various tissues, and it has a great effect on nitrogen signaling in retinal pigment epithelial cells and vascular smooth muscle cells. While many studies attest a role for betacellulin in the differentiation of pancreatic β-cells, the last decade witnessed the association of betacellulin with many additional biological processes, ranging from reproduction to the control of neural stem cells. Betacellulin is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events.