American Music Awards of 2021

American Music Awards of 2021
DateNovember 21, 2021
VenueMicrosoft Theater, Los Angeles
CountryUnited States
Hosted byCardi B
Most wins
Most nominationsOlivia Rodrigo (7)
Websitetheamas.com
Television/radio coverage
NetworkABC
Produced byJesse Collins Entertainment
MRC Live & Alternative

The 49th Annual American Music Awards were held on November 21, 2021, at the Microsoft Theater in Los Angeles, recognizing the most popular artists, singles and albums of 2021. Cardi B hosted the ceremony, following Queen Latifah (1995) as the only female rappers in history to do so. Cardi B became the first artist to win Favorite Rap/Hip Hop Song three times. BTS, Doja Cat, and Megan Thee Stallion won three awards each.

The ceremony was notable as the first produced under the banner of MRC Live & Alternative, which was formerly known as Dick Clark Productions after use of that name was phased out the month before. However, this would turn out to be the only year produced under this banner, as the Dick Clark Productions name was restored in August 2022.