American Dad! season 21

The twenty-first season of American Dad! premiered on TBS on October 28, 2024, and ended on March 24, 2025. The season featured guest appearances from Kevin Bacon, Charles Barkley, Bret Hart, Gabriel Iglesias, Michael Imperioli, Leslie Jones, Neal McDonough, Joel McHale, and Kyra Sedgwick. The series focuses on the eccentric upper middle class Smith family in a fictionalized version of Langley, Virginia and their eight housemates: Father, husband, CIA agent, and Republican, Stan; his wife and housewife, Francine; their liberal, hippie, college-aged daughter, Hayley-Fischer; their dorky high-school-aged son, Steve; the family's unusual goldfish, Klaus; flamboyant, master of disguise alien, Roger; Jeff Fischer, Hayley Smith's stoner husband who resides with the Smith family; And Roger's ex-tumor son Rogu. Season 21 aired weekly without breaks throughout October 2024 to March 2025.

It was the tenth and final season to premiere on TBS as the series would return to its original network Fox in 2026.