2025 Argentina Open – Singles

Singles
2025 Argentina Open
Champion João Fonseca
Runner-up Francisco Cerúndolo
Score6–4, 7–6(7–1)
Draw28 (4 Q / 3 WC )
Seeds8

João Fonseca defeated Francisco Cerúndolo in the final, 6–4, 7–6(7–1) to win the singles tennis title at the 2025 Argentina Open. He saved two match points (in the quarterfinals against Mariano Navone) en route to his first ATP Tour title. Fonseca was the youngest Brazilian man and the second-youngest South American in the Open Era, behind only Guillermo Pérez Roldán in 1987, and the first man born in 2006, to win a top-level title. He entered the tournament through the Next Gen Accelerator Program introduced by the ATP in 2024, being the first player entered under the system to win a tour-level title. Fonseca was the first Brazilian man to win the Argentina Open title since Gustavo Kuerten in 2001, and the lowest-ranked champion (world No. 99) in tournament history.

Facundo Díaz Acosta was the defending champion, but lost in the first round to Thiago Seyboth Wild.

This tournament marked the final professional appearance of former world No. 8 Diego Schwartzman. He defeated seventh seed Nicolás Jarry in the first round, before losing in the second round to Pedro Martínez.