2022 US Open – Wheelchair girls' singles
| Wheelchair girls' singles | |
|---|---|
| 2022 US Open | |
| Champion | Jade Lanai Oliveira Moreira |
| Runner-up | Yuma Takamuro |
| Score | 7–5, 2–6, 7–6[10–5] |
The 2022 US Open wheelchair girls' singles tournament was part of the US Open Wheelchair Championships held at the USTA Billie Jean King National Tennis Center. This tournament marked a historic moment for wheelchair tennis as it featured the first-ever junior wheelchair singles competition at the US Open.