2022 Mutua Madrid Open – Women's singles

Women's singles
2022 Mutua Madrid Open
Champion Ons Jabeur
Runner-up Jessica Pegula
Score7–5, 0–6, 6–2
Draw64
Seeds16

Ons Jabeur defeated Jessica Pegula in the final, 7–5, 0–6, 6–2 to win the women's singles tennis title at the 2022 Madrid Open. It was her first WTA 1000 title, and she became the first Arab and African woman to win a WTA 1000 title.

Aryna Sabalenka was the defending champion, but lost in the first round to Amanda Anisimova.

Pegula reached the final after being a match point down against Camila Giorgi in the first round.

This marked the last professional appearance of 2016 Olympic gold medalist Monica Puig; she lost to Danielle Collins in the first round.