2021 Eastbourne International – Men's singles
| Men's singles | |
|---|---|
| 2021 Eastbourne International | |
| Champion | Alex de Minaur |
| Runner-up | Lorenzo Sonego |
| Score | 4–6, 6–4, 7–6(7–5) |
Alex de Minaur defeated Lorenzo Sonego in the final, 4–6, 6–4, 7–6(7–5), to win the men's singles tennis title at the 2021 Eastbourne International. It was de Minaur's fifth career ATP Tour singles title and his first on grass. Sonego was contesting in his second grass final to win his third career title.
Taylor Fritz was the defending champion from when the event was last held in 2019, but he withdrew before the beginning of the tournament after incurring a knee injury during the French Open.