2021 Australian Open – Wheelchair women's singles

Wheelchair women's singles
2021 Australian Open
Champion Diede de Groot
Runner-up Yui Kamiji
Score6–3, 6–7(4–7), 7–6(10–4)
Draw8
Seeds2

Diede de Groot defeated the defending champion Yui Kamiji in the final, 6–3, 6–7(4–7), 7–6(10–4) to win the women's singles wheelchair tennis title at the 2021 Australian Open. It was the first step in an eventual Super Slam for de Groot.