2021 Argentina Open – Singles

Singles
2021 Argentina Open
Champion Diego Schwartzman
Runner-up Francisco Cerúndolo
Score6–1, 6–2
Draw28 (4 Q / 3 WC )
Seeds8

Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.

Casper Ruud was the defending champion, but chose not to participate.

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