2021 Argentina Open – Singles
| Singles | |
|---|---|
| 2021 Argentina Open | |
| Champion | Diego Schwartzman |
| Runner-up | Francisco Cerúndolo |
| Score | 6–1, 6–2 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.
Casper Ruud was the defending champion, but chose not to participate.