2018 ATP Lyon Open – Singles
| Singles | |
|---|---|
| 2018 ATP Lyon Open | |
| Champion | Dominic Thiem |
| Runner-up | Gilles Simon |
| Score | 3–6, 7–6(7–2), 6–1 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Jo-Wilfried Tsonga was the defending champion, but due to injury did not defend his title.
Dominic Thiem won the title, defeating Gilles Simon in the final, 3–6, 7–6(7–2), 6–1.