2016 Western & Southern Open – Men's singles

Men's singles
2016 Western & Southern Open
Champion Marin Čilić
Runner-up Andy Murray
Score6–4, 7–5
Draw64 (7Q / 4WC)
Seeds16

Marin Čilić defeated Andy Murray in the final, 6–4, 7–5 to win the men's singles tennis title at the 2016 Cincinnati Masters. It was his maiden Masters 1000 title, ending a streak of 18 consecutive Masters events won by a member of the Big Four.

Roger Federer was the two-time reigning champion, but withdrew due to a knee injury.

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