2012 Mutua Madrid Open – Women's singles
| Women's singles | |
|---|---|
| 2012 Mutua Madrid Open | |
| Champion | Serena Williams |
| Runner-up | Victoria Azarenka |
| Score | 6–1, 6–3 |
Serena Williams defeated Victoria Azarenka in the final, 6–1, 6–3 to win the women's singles tennis title at the 2012 Madrid Open. It was Azarenka's second consecutive runner-up finish at the event.
Petra Kvitová was the defending champion, but lost to Lucie Hradecká in the second round.