2012 Mutua Madrid Open – Women's singles

Women's singles
2012 Mutua Madrid Open
Champion Serena Williams
Runner-up Victoria Azarenka
Score6–1, 6–3

Serena Williams defeated Victoria Azarenka in the final, 6–1, 6–3 to win the women's singles tennis title at the 2012 Madrid Open. It was Azarenka's second consecutive runner-up finish at the event.

Petra Kvitová was the defending champion, but lost to Lucie Hradecká in the second round.