2010 Mutua Madrileña Madrid Open – Women's singles

Women's singles
2010 Mutua Madrileña Madrid Open
Champion Aravane Rezaï
Runner-up Venus Williams
Score6–2, 7–5

Aravane Rezaï defeated Venus Williams in the final, 6–2, 7–5 to win the women's singles tennis title at the 2010 Madrid Open.

Dinara Safina was the defending champion, but lost to Klára Zakopalová in the first round.

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