2010–11 Uruguayan Primera División season

Liga Profesional de Primera División
Season	2010–11
Champions	Nacional (43rd title)
Relegated	Central Español; Tacuarembó; Miramar Misiones
2012 Copa Libertadores	Nacional; Defensor Sporting; Peñarol
2011 Copa Sudamericana	Nacional; Fénix; Bella Vista
Matches played	241
Goals scored	671 (2.78 per match)
Top goalscorer	Apertura: Santiago García (15 goals); Clausura: Cristian Palacios (15 goals); Overall: Santiago García (23 goals);
Biggest home win	Racing 6–0 Danubio; (May 7, 2011)
Biggest away win	Cerro 1–5 Central Español; (Feb. 13, 2011); Miramar Misiones 0–4 Liverpool; (May 21, 2011); Miramar Misiones 0–4 Montevideo Wanderers; (Jun. 4, 2011)
Highest scoring	Central Español 3–5 El Tanque Sisley; (Oct. 3, 2010)
Longest winning run	7 matches: Nacional; (Mar. 29, 2011–Apr. 10, 2011)
Longest unbeaten run	9 matches:; Liverpool; (Sep. 26, 2010–Nov. 21, 2010); Nacional; (Oct. 17, 2010–Feb. 5, 2011)
Longest winless run	11 matches:; Tacuarembó; (Sep. 25, 2010–Dec. 5, 2010); Miramar Misiones; (Sep. 25, 2010–Dec. 4, 2010)
Longest losing run	9 matches: Tacuarembó; (Oct. 10, 2010–Dec. 5, 2010)
	← 2009–10 2011–12 →

The 2010–11 Liga Profesional de Primera División season, also known as the 2010–11 Copa Uruguaya or the 2010–11 Campeonato Uruguayo, was the 107th season of Uruguay's top-flight football league, and the 80th in which it was professional.

Nacional won their 43rd Primera División title after defeating Defensor Sporting in the season-ending final.