2006 NASDAQ-100 Open – Women's singles

Women's singles
2006 NASDAQ-100 Open
Champion Svetlana Kuznetsova
Runner-up Maria Sharapova
Score6–4, 6–3
Draw96
Seeds32

Svetlana Kuznetsova defeated Maria Sharapova in the final, 6–4, 6–3 to win the women's singles tennis title at the 2006 Miami Open. It was her first Tier I title and sixth overall, and her first title of any kind since September 2004.

Kim Clijsters was the defending champion, but lost in the second round to Jill Craybas.

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