2005 Australian Open – Women's singles

Serena Williams defeated Lindsay Davenport in the final, 2–6, 6–3, 6–0 to win the women's singles tennis title at the 2005 Australian Open. It was her second Australian Open singles title and her seventh major singles title overall. Just as during her first Australian Open title run, Williams saved match points en route to the title, saving three in the semifinals against Maria Sharapova.

Justine Henin-Hardenne was the reigning champion, but did not compete this year due to a knee injury.

This event marked the first major appearances for future world No. 1 and major champion Ana Ivanovic and two-time major champion Li Na. Both reached the third round before losing to Amélie Mauresmo and Sharapova, respectively.